Italian guidelines for the diagnosis and treatment of classic and iatrogenic Kaposi's sarcoma
Articolo
Data di Pubblicazione:
2020
Citazione:
Italian guidelines for the diagnosis and treatment of classic and iatrogenic Kaposi's sarcoma / L. Brambilla, G. Genovese, E. Berti, K. Peris, F. Rongioletti, G. Micali, F. Ayala, S. Della Bella, R. Mancuso, P. Calzavara Pinton, A. Tourlaki. - In: GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA. - ISSN 1827-1820. - (2020 Nov 12). [Epub ahead of print]
Abstract:
Kaposi's sarcoma (KS) is a lymphangioproliferative disorder associated with human herpesvirus 8 (HHV8) infection. Four clinical subtypes are recognized: classic, endemic, epidemic (HIV-related) and iatrogenic. KS diagnosis is based on clinical features, histopathological assessment, and HHV8 serology. Classic KS is usually skin-limited and has a chronic course, while the iatrogenic variant may show mucosal, nodal or visceral involvement. Clinical staging is fundamental to guide the management. Localized disease may be treated with different local therapies, even if there are no randomized trials comparing these different modalities. Aggressive, disseminated KS and cases with visceral involvement usually require systemic chemotherapy, most commonly vinblastine, bleomycin or paclitaxel. Iatrogenic KS needs immunosuppression tapering/withdrawal and, if possible, switch to m-TOR inhibitors in post-transplant KS. The present work by a panel of Italian experts provides guidelines on KS diagnosis and management based on a critical review of the literature and a long and extensive personal experience.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
L. Brambilla, G. Genovese, E. Berti, K. Peris, F. Rongioletti, G. Micali, F. Ayala, S. Della Bella, R. Mancuso, P. Calzavara Pinton, A. Tourlaki
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