Associations between first trimester maternal nutritional score, early markers of placental function, and pregnancy outcome
Articolo
Data di Pubblicazione:
2020
Citazione:
Associations between first trimester maternal nutritional score, early markers of placental function, and pregnancy outcome / F. Parisi, V.M. Savasi, I. Di Bartolo, L. Mandia, I. Cetin. - In: NUTRIENTS. - ISSN 2072-6643. - 12:6(2020 Jun 17). [10.3390/nu12061799]
Abstract:
This study investigated the associations between maternal adherence to a healthy diet, first trimester placental markers, and pregnancy outcome. Singleton spontaneous pregnancies were enrolled at 11+0–13+6 gestational weeks in a prospective cohort study. A nutritional score (0–10) measuring the adherence to a healthy diet was calculated. A transabdominal ultrasound scan for placental marker assessment was performed (uterine artery (UtA) doppler, placental volume). Biochemical placental markers were recorded (Pregnancy Associated Plasma Protein A (PAPP-A), free β-Human Chorionic Gonadotropin (HCG)). Birth outcomes were obtained from medical records. Associations between the maternal nutritional score, first trimester placental markers, and pregnancy outcome were investigated by using multi-adjusted general linear models. In total, 112 pregnancies were enrolled with a median nutritional score of 7 (range 3–10). Median gestational age at birth was 277 days (range 203–296). The nutritional score was positively associated with PAPP-A concentrations, whereas a negative association was detected with the UtA mean pulsatility index and placental volume. A positive association was detected between nutritional score and gestational age at birth. This study demonstrates that a first trimester nutritional score as a measure of adherence to a healthy diet is significantly associated with early biochemical and ultrasound markers of placental development, with further association with gestational age at birth.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
First trimester placental markers; Healthy diet; Maternal nutrition; Placental volume; Preterm delivery
Elenco autori:
F. Parisi, V.M. Savasi, I. Di Bartolo, L. Mandia, I. Cetin
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