A possible role of Fas antigen in ejaculated spermatozoa of fertile bulls : an immunocytochemical quantitative approach
Articolo
Data di Pubblicazione:
2006
Citazione:
A possible role of Fas antigen in ejaculated spermatozoa of fertile bulls : an immunocytochemical quantitative approach / D. Meggiolaro, F. Porcelli, A. Carnevali, P. Crepaldi, E. Savarese, B. Ferrandi. - In: ACTA HISTOCHEMICA. - ISSN 0065-1281. - 107:6(2006 Feb 20), pp. 463-468.
Abstract:
The Fas/Fas L system is a widely recognized apoptosis signal transduction pathway in
which transmembrane receptor protein (Fas) triggers a programmed cell death when
bound by the Fas ligand (Fas L). This system in the testis is believed to be a paracrine
signaling system by which Sertoli cells expressing Fas L can initiate killing of Fasexpressing
germ cells during spermatogenesis. So far, the presence of Fas antigen in
ejaculated spermatozoa was related only to subfertility or infertility conditions. We
demonstrated for the first time that normal ejaculated spermatozoa also express Fas
antigen. Our data showed that a large percentage of normal ejaculated spermatozoa
of fertile bulls are immunocytochemically positive for Fas. Our observations provide
further evidence of the ‘‘regionalization’’ of sperm membrane antigens. Furthermore,
we suggest that in mature fertile ejaculated spermatozoa the Fas antigen may
also provide resistance to programmed cell death, like in some other cells expressing
molecules that inhibit the signals induced by Fas or the death program itself. In
addition, we suggest that Fas antigen can partly protect the spermatozoa against
apoptosis induced by lipoperoxidative damage that can occur spontaneously in the
male gamete at various stages in its lifetime.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
fas antigen ; fas receptor ; bull spermatozoa ; immunocytochemistry ; apoptosis
Elenco autori:
D. Meggiolaro, F. Porcelli, A. Carnevali, P. Crepaldi, E. Savarese, B. Ferrandi
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