Data di Pubblicazione:
2014
Citazione:
Photofunctional nanomodulators for bioexcitation / E. Miyako, J. Russier, M. Mauro, C. Cebrian, H. Yawo, C. Menard-Moyon, J.A. Hutchison, M. Yudasaka, S. Iijima, L. De Cola, A. Bianco. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 53:48(2014), pp. 13121-13125. [10.1002/anie.201407169]
Abstract:
A single organism comprises diverse types of cells. To acquire a detailed understanding of the biological functions of each cell, comprehensive control and analysis of homeostatic processes at the single-cell level are required. In this study, we develop a new type of light-driven nanomodulator comprising dye-functionalized carbon nanohorns (CNHs) that generate heat and reactive oxygen species under biologically transparent near-infrared (NIR) laser irradiation. By exploiting the physicochemical properties of the nanohorns, cellular calcium ion flux and membrane currents were successfully controlled at the single-cell level. In addition, the nanomodulator allows a remote bioexcitation of tissues during NIR laser exposure making this system a powerful tool for single-cell analyses and innovative cell therapies.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Biological activity; Laser chemistry; Nanomaterials; Nanotechnology
Elenco autori:
E. Miyako, J. Russier, M. Mauro, C. Cebrian, H. Yawo, C. Menard-Moyon, J.A. Hutchison, M. Yudasaka, S. Iijima, L. De Cola, A. Bianco
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