Data di Pubblicazione:
2016
Citazione:
Breakable mesoporous silica nanoparticles for targeted drug delivery / L. Maggini, I. Cabrera, A. Ruiz-Carretero, E.A. Prasetyanto, E. Robinet, L. De Cola. - In: NANOSCALE. - ISSN 2040-3364. - 8:13(2016), pp. 7240-7247. [10.1039/c5nr09112h]
Abstract:
"Pop goes the particle". Here we report on the preparation of redox responsive mesoporous organo-silica nanoparticles containing disulfide (S-S) bridges (ss-NPs) that, even upon the exohedral grafting of targeting ligands, retained their ability to undergo structural degradation, and increase their local release activity when exposed to a reducing agent. This degradation could be observed also inside glioma C6 cancer cells. Moreover, when anticancer drug-loaded pristine and derivatized ss-NPs were fed to glioma C6 cells, the responsive hybrids were more effective in their cytotoxic action compared to non-breakable particles. The possibility of tailoring the surface functionalization of this hybrid, yet preserving its self-destructive behavior and enhanced drug delivery properties, paves the way for the development of effective biodegradable materials for in vivo targeted drug delivery.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
intracellular drug; organosilica nanoparticles; cancer; copolymer; cells; diodegradability; micelles
Elenco autori:
L. Maggini, I. Cabrera, A. Ruiz-Carretero, E.A. Prasetyanto, E. Robinet, L. De Cola
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