Data di Pubblicazione:
2018
Citazione:
Cardiac Troponin I : Ultrasensitive Detection Using Faradaic Electrochemical Impedance / E. Spain, S. Carrara, K. Adamson, H. Ma, R. O'Kennedy, L. De Cola, R.J. Forster. - In: ACS OMEGA. - ISSN 2470-1343. - 3:12(2018), pp. 17116-17124. [10.1021/acsomega.8b01758]
Abstract:
An electrochemical biosensor for the detection of cardiac troponin I, cTnI, an important cardiac biomarker, is described. A combination of a novel monoclonal antibody, mAb20B3, and a novel Ir(III)-based metal complex was used for detection using faradaic electrochemical impedance spectroscopy. A limit of detection of 10 ag/mL was achieved, which is significantly lower than established assays. The ability to detect these ultralow concentrations enables rapid and early stage detection of cardiac events and opens up the possibility of developing a point-of-care device.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
E. Spain, S. Carrara, K. Adamson, H. Ma, R. O'Kennedy, L. De Cola, R.J. Forster
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