Data di Pubblicazione:
2014
Citazione:
Primary “amyloid tumor” of the mammary gland in a dog / C. Giudice, V. Baldassarre, L. Turati, M. Rondena, V. Grieco. ((Intervento presentato al 68. convegno Convegno Nazionale SISVet tenutosi a Pisa nel 2014.
Abstract:
The present report describes an unusual mammary lesion in a dog, with gross and histological features
similar to the lesion known as “amyloid tumor of the breast” in the woman.
A fourteen year-old female spayed Dalmatian dog was presented to the practitioner with a large, bilobated
lump involving left and right IV mammary gland. The mass was surgically excised and submitted for
histopathological examination.
Grossly, two large subcutaneous nodular, firm masses, merging on the median line, expanded left and right
IV mammary glands. Histologically, masses were encapsulated and mainly composed of large, coalescing
lakes of pale eosinophilic, homogenous hyaline amorphous material, that stained positive with Congo Red
(amyloid). Numerous plasma cells with moderate anysocytosis and anysokariosis and rare mitoses were
multifocally recognizable. Multinucleated giant cells (MNGCs) with nuclear features similar to plasma cells
were occasionally present. Moreover, MNGCs with scant eosinophilic cytoplasm and up to 25 dense nuclei
were visible closely associated with amyloid deposits. Moderately atrophic mammary parenchyma was
present at periphery. Immunohistochemistry (ABC method) was performed to characterize MNGCs and
amyloid, applying anti-Lysozyme; Lambda-light-immunoglobulin-chains and HLA antibodies. Plasma cells
and MNGCs were Lysozyme and HLA negative. Lambda-chains stained plasma cells, the majority of MNGCs
and amyloid (AL amyloid).
Bilateral mammary extramedullary plasmacytoma with abundant AL amyloid deposition was diagnosed.
Clinical workup did not reveal systemic amyloidosis or multiple myeloma. Sixteen months later the dog was
humanely killed because of cardiac failure. No signs of multiple myeloma or recurrence of the tumor were
reported.
Primary amyloidosis of the breast not associated with mammary carcinoma (amyloidoma), is a rare entity
that has been documented in women since 1973, affecting mostly elderly patients, with bilateral
involvement and related neither to systemic amyloidosis nor to multiple myeloma. Despite similar gross
and histological appearance, some cases have been described as primary amyloidosis, while others as
plasmacytoma with massive amyloid deposition
In the canine species, mammary gland amyloid deposition was described in association with mammary
carcinoma whereas mammary primary amyloidosis or plasmacytoma with massive amyloid deposition have
never been reported so far. To the best of author’s knowledge this is the first report in the dog of a bilateral
mammary extramedullary plasmacytoma with features consistent with primary amyloidoma of the breast
in the woman.
Tipologia IRIS:
14 - Intervento a convegno non pubblicato
Elenco autori:
C. Giudice, V. Baldassarre, L. Turati, M. Rondena, V. Grieco
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