Data di Pubblicazione:
2016
Citazione:
Urachal Carcinoma in a Young Adult Dog / M. Rondena, C. Giudice, D. Stefanello, D. Zani, V. Giacobbi, V. Baldassarre. ((Intervento presentato al convegno 34th Annual Meeting of the ESVP & 27th Annual Meeting of the ECVP tenutosi a Bologna nel 2016.
Abstract:
Introduction: Tumours arising from embryonal remnants are rare;
among these urachal carcinoma (UC) is reported sporadically in
man, mostly in adult and aged patients, and less frequently in children
and adolescents. To our knowledge UC has never been reported
in dogs.
Materials and Methods: An 18-month-old, male, Labrador
retriever dog was referred for abdominal pain. Ultrasonography revealed
multiple large (up to 25 cm) cystic abdominal masses,
adherent to the omentum and close to the pancreas and spleen.
The largest mass was removed surgically and formalin fixed for histology.
Immunohistochemistry with antibodies against cytokeratin and
uroplakin III was also performed. Computed tomography examination
did not reveal findings compatible with metastatic lesions. A
postoperative change in chemotherapy was performed.
Results: Histologically, a large, multinodular, partially encapsulated,
infiltrating, cystic neoplasm, involving mesenteric fat was
observed. The neoplasm was composed of small cystic structures lined
either by simple columnar epithelium with intermingled goblet cells
(intestinal type) or by pseudostratified epithelium with 4e5 rows of
nuclei and occasionally superficial luminal ‘umbrella’ cells (urothelial
type). Immunohistochemically, all neoplastic cells were intensely and
diffusely cytokeratin positive. In urothelial type areas, neoplastic cells
also showed intense intracytoplasmic expression of uroplakin III.
Twelve months after surgery, the dog is still alive and in very good
clinical condition without relapse.
Conclusions: UC is rare in human medicine and is characterized by
double intestinal (colonic) and urothelial differentiation. Metastatic
cases are reported, with variable fates. The present case is the first
report of UC in dogs. The diagnosis was possible based on both histology
and immunohistochemistry.
Tipologia IRIS:
14 - Intervento a convegno non pubblicato
Elenco autori:
M. Rondena, C. Giudice, D. Stefanello, D. Zani, V. Giacobbi, V. Baldassarre
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