A Systematic Review of Promising Therapeutic Targets in Hidradenitis Suppurativa : A Critical Evaluation of Mechanistic and Clinical Relevance
Articolo
Data di Pubblicazione:
2021
Citazione:
A Systematic Review of Promising Therapeutic Targets in Hidradenitis Suppurativa : A Critical Evaluation of Mechanistic and Clinical Relevance / J.W. Frew, A.V. Marzano, K. Wolk, O. Join-Lambert, A. Alavi, M.A. Lowes, V. Piguet. - In: JOURNAL OF INVESTIGATIVE DERMATOLOGY. - ISSN 0022-202X. - 141:2(2021), pp. 316-324. [10.1016/j.jid.2020.06.019]
Abstract:
This systematic review identifies and critically evaluates the mechanistic and clinical evidence of new promising therapeutic targets in hidradenitis suppurativa (HS). Evidence for these targets is largely based on observational data with limited ex vivo and translational data from clinical trials. A number of placebo-controlled studies have been completed or are underway utilizing IL-1, IL-23, IL-17, complement, and Jak inhibition, although there is concern regarding elevated placebo response rates and the questionable validity of clinical scores in some participant subsets. Knowledge gaps are identified suggesting a direction for future mechanistic studies in HS, including more comprehensive inflammatory endotype profiling of disease.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Growth-factor-beta; elevated levels; TNF-alpha; moderate; placebo; pathway; disease; skin; acne; inflammation
Elenco autori:
J.W. Frew, A.V. Marzano, K. Wolk, O. Join-Lambert, A. Alavi, M.A. Lowes, V. Piguet
Link alla scheda completa: