Cutaneous-group histiocytoses associated with myeloid malignancies: A systematic review of 102 cases
Articolo
Data di Pubblicazione:
2020
Citazione:
Cutaneous-group histiocytoses associated with myeloid malignancies: A systematic review of 102 cases / A. Bonometti, J. Gliozzo, C. Moltrasio, F. Bagnoli, E. Berti. - In: AUSTRALASIAN JOURNAL OF DERMATOLOGY. - ISSN 0004-8380. - (2020). [Epub ahead of print] [10.1111/ajd.13491]
Abstract:
Background: Histiocytoses are haematological disorders of bone marrow origin that share many biological and clinical features with haematological neoplasms. The association between histiocytoses of the cutaneous-group and myeloid malignancies is a poorly investigated topic of high biological and clinical impact.
Methods: We performed a systematic review of the scientific literature, compliant with PRISMA guidelines, to unravel the clinical and pathological features of this intriguing association.
Findings: We gathered and analysed 102 patients. Most were children with generalised cutaneous eruptions and displayed risk organ involvement (i.e. bone marrow, spleen, liver). Interestingly, all these features are uncommonly encountered in C-group histiocytosis not associated with haematological neoplasms.
Conclusions: Our review shows that generalised eruptions and risk organ involvement in cutaneous-group histiocytosis should raise a suspicion for a concomitant myeloid neoplasm both in children and in adults and warrant further investigations. A rapid recognition of this association is required to start a prompt and effective therapeutic management given the aggressive behaviour of the associated myeloid neoplasm in most instances.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
association; histiocytoses; leukaemia cutis; myeloid neoplasms; systematic review;
Elenco autori:
A. Bonometti, J. Gliozzo, C. Moltrasio, F. Bagnoli, E. Berti
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