Diagnostic and predictive value of Doppler ultrasound for evaluation of the brain circulation in preterm infants : a systematic review
Articolo
Data di Pubblicazione:
2020
Citazione:
Diagnostic and predictive value of Doppler ultrasound for evaluation of the brain circulation in preterm infants : a systematic review / F.A. Camfferman, R. de Goederen, P. Govaert, J. Dudink, F. van Bel, A. Pellicer, F. Cools, T. Agut, A. Alarcon, R. Arena, M. Bartocci, M. Bravo, F. Cabanas, N. Carreras, O. Claris, J. Dudink, M. Fumagalli, P. Govaert, S. Horsch, A. Parodi, A. Pellicer, L. Ramenghi, C.C. Roehr, S. Steggerda, E. Valverde. - In: PEDIATRIC RESEARCH. - ISSN 0031-3998. - 87:suppl. 1(2020 Mar), pp. 50-58. [10.1038/s41390-020-0777-x]
Abstract:
Introduction: Very and extremely preterm infants frequently have brain injury-related long-term neurodevelopmental problems. Altered perfusion, for example, seen in the context of a hemodynamically significant patent ductus arteriosus (PDA), has been linked to injury of the immature brain. However, a direct relation with outcome has not been reviewed systematically. Methods: A systematic review was conducted to provide an overview of the value of different cerebral arterial blood flow parameters assessed by Doppler ultrasound, in relation to brain injury, to predict long-term neurodevelopmental outcome in preterm infants. Results: In total, 23 studies were included. Because of heterogeneity of studies, a meta-analysis of results was not possible. All included studies on resistance index (RI) showed significantly higher values in subjects with a hemodynamically significant PDA. However, absolute differences in RI values were small. Studies using Doppler parameters to predict brain injury and long-term neurodevelopmental outcome were inconsistent. Discussion: There is no clear evidence to support the routine determination of RI or other Doppler parameters in the cerebral arteries to predict brain injury and long-term neurodevelopmental outcome in the preterm infant. However, there is evidence that elevated RI can point to the presence of a hemodynamically significant PDA.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
F.A. Camfferman, R. de Goederen, P. Govaert, J. Dudink, F. van Bel, A. Pellicer, F. Cools, T. Agut, A. Alarcon, R. Arena, M. Bartocci, M. Bravo, F. Cabanas, N. Carreras, O. Claris, J. Dudink, M. Fumagalli, P. Govaert, S. Horsch, A. Parodi, A. Pellicer, L. Ramenghi, C.C. Roehr, S. Steggerda, E. Valverde
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