Sensitivity and specificity of a commercial ELISA test for anti-MAG antibodies in patients with neuropathy
Articolo
Data di Pubblicazione:
2020
Citazione:
Sensitivity and specificity of a commercial ELISA test for anti-MAG antibodies in patients with neuropathy / G. Liberatore, C. Giannotta, B.P. Sajeev, E. Morenghi, F. Terenghi, F. Gallia, P.E. Doneddu, F. Manganelli, D. Cocito, M. Filosto, G. Antonini, G. Cosentino, G.A. Marfia, A.M. Clerici, G. Lauria, T. Rosso, G. Cavaletti, E. Nobile-Orazio. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 345:(2020 Aug 15). [10.1016/j.jneuroim.2020.577288]
Abstract:
For the diagnosis of anti-MAG polyneuropathy the commercial ELISA manufacturer currently recommends a cut-off of 1000 Bühlmann Titer Units (BTU). We analyzed sera from 80 anti-MAG neuropathy patients and 383 controls (with other neuropathies or healthy controls) to assess the ELISA sensitivity and specificity at different thresholds. A better combination of sensitivity/specificity was found at a threshold >1500 BTU than at >1000 BTU. The best value of specificity was obtained at threshold >7000 BTU. There was a diagnostic grey area between 1500 and 7000 BTU in which the clinical phenotypes as well as electrophysiological studies need to be carefully assessed particularly to differentiate CIDP and anti-MAG neuropathy.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Anti-MAG polyneuropathy, chronic inflammatory demyelinating polyradiculoneuropathy; ELISA; Sensitivity; Specificity
Elenco autori:
G. Liberatore, C. Giannotta, B.P. Sajeev, E. Morenghi, F. Terenghi, F. Gallia, P.E. Doneddu, F. Manganelli, D. Cocito, M. Filosto, G. Antonini, G. Cosentino, G.A. Marfia, A.M. Clerici, G. Lauria, T. Rosso, G. Cavaletti, E. Nobile-Orazio
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