Data di Pubblicazione:
2021
Citazione:
Impact of protein glycosylation on lipoprotein metabolism and atherosclerosis / A. Pirillo, M. Svecla, A.L. Catapano, A.G. Holleboom, G.D. Norata. - In: CARDIOVASCULAR RESEARCH. - ISSN 0008-6363. - 117:4(2021 Apr 01), pp. 1033-1045.
Abstract:
Protein glycosylation is a post-translational modification consisting of the enzymatic attachment of carbohydrate chains to specific residues of the protein sequence. Several types of glycosylation have been described, with N-glycosylation and O-glycosylation being the most common types impacting on crucial biological processes, such as protein synthesis, trafficking, localization, and function. Genetic defects in genes involved in protein glycosylation may result in altered production and activity of crucial proteins, with a broad range of clinical manifestations, including dyslipidemia and atherosclerosis. A large number of apolipoproteins, lipoprotein receptors, and other proteins involved in lipoprotein metabolism are glycosylated, and alterations in their glycosylation profile are associated with changes in their expression and/or function. Rare genetic diseases and population genetics have provided additional information linking protein glycosylation to the regulation of lipoprotein metabolism.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
glycosylation; atherosclerosis; dyslipidaemias
Elenco autori:
A. Pirillo, M. Svecla, A.L. Catapano, A.G. Holleboom, G.D. Norata
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