Fabrication, Mercury Intrusion Porosimetry Characterization and In Vitro Qualitative Analysis of Biocompatibility of Various Porosities Polycaprolactone Scaffolds
Articolo
Data di Pubblicazione:
2015
Citazione:
Fabrication, Mercury Intrusion Porosimetry Characterization and In Vitro Qualitative Analysis of Biocompatibility of Various Porosities Polycaprolactone Scaffolds / T. Limongi, A. Giugni, H. Tan, E. Bukhari, B. Torre, M. Allione, M. Marini, L. Tirinato, G. Das, M. Moretti, A. Falqui, E. Di Fabrizio. - In: JOURNAL OF TISSUE SCIENCE & ENGINEERING. - ISSN 2157-7552. - 6:3(2015 Dec), pp. 1000159.1-1000159.6. [10.4172/2157-7552.1000159]
Abstract:
In order to develop surfaces with improved cell culture biocompatibility, we optimized a solvent-casting and
particulate-leaching fabrication technique to create porous three-dimensional polycaprolactone scaffolds. These
biocompatible porous surfaces were realized by means of NaCl particles as porogen; salt leaching by immersion
in distilled water created porosity and pore interconnectivity in the material. Scanning electron microscopy and
mercury intrusion porosimetry were used for the measurement of porosity, pore size distribution, permeability and
compressibility. To evaluate scaffold biocompatibility, fibroblasts were cultured on the porous surfaces and confocal
immunofluorescence characterization indicated that they were effective for in vitro cell culture and practical tissue
engineering applications.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Tissue engineering; Biocompatibility; Biomaterials; Porosity; Porogens; Polycaprolactone; Fibroblasts
Elenco autori:
T. Limongi, A. Giugni, H. Tan, E. Bukhari, B. Torre, M. Allione, M. Marini, L. Tirinato, G. Das, M. Moretti, A. Falqui, E. Di Fabrizio
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