Blood levels of homocysteine, folate, vitamin B-6 and B-12 in women using oral contraceptives compared to non-users
Articolo
Data di Pubblicazione:
2004
Citazione:
Blood levels of homocysteine, folate, vitamin B-6 and B-12 in women using oral contraceptives compared to non-users / F. Lussana, M.L. Zighetti, P. Bucciarelli, M. Cugno, M. Cattaneo. - In: THROMBOSIS RESEARCH. - ISSN 0049-3848. - 112:1-2(2004), pp. 37-41. [10.1016/j.thromres.2003.11.007]
Abstract:
Background and objectives: To compare the levels of total homocysteine (tHcy), folate, vitamin B-6 and B-12, in women not using oral contraceptives (OC) vs. those using OC. Materials and methods: 219 healthy women were enrolled in the study; 159 of them had not been using OC for at least 12 months prior to their enrolment, while 60 were on regular OC treatment. Results: The median levels of vitamin B-6 and B-12 were significantly lower in OC users than in non-users (24.2 vs. 32.9 nmol/l, p = 0.029; 278 vs. 429 ng/ml, p < 0.001). There were no statistically significant differences in the levels of tHcy (fasting and post-methionine loading) and folate. Conclusions: In our cross-sectional study, OC use was associated with low vitamin B-6 and B-12 levels. Since low vitamin B-6 levels are independently associated with heightened risks for arterial and venous thromboembolism (TE), they could partly account for the increased TE risk of OC users.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
coronary-artery-disease ; plasma homocysteine ; risk-factors ; menopausal status ; heart-disease ; cross-over ; thrombosis ; hyperhomocysteinemia ; matabolism ; serum
Elenco autori:
F. Lussana, M.L. Zighetti, P. Bucciarelli, M. Cugno, M. Cattaneo
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