Laboratory-related issues in the measurement of cardiac troponins with highly sensitive assays
Articolo
Data di Pubblicazione:
2020
Citazione:
Laboratory-related issues in the measurement of cardiac troponins with highly sensitive assays / M. Krintus, M. Panteghini. - In: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. - ISSN 1434-6621. - (2020). [Epub ahead of print] [10.1515/cclm-2020-0017]
Abstract:
A number of assay-related issues can affect the performance of cardiac troponin (cTn) measurement in everyday practice. In this respect, it is vital that all information on cTn assays is known and that the performance characteristics of assays are objectively assessed and adequately described. The advent of the latest generation
of more sensitive cTn assays has heralded a new wave of information about low concentrations of cTn in blood. These recent generation assays have improved
analytical sensitivity and corresponding performance at low cTn concentrations when compared to their predecessors, providing a convincing goal for laboratory medicine
in helping clinicians in the diagnosis of acute myocardial infarction. Crucial to the clinical utility of highly sensitive cTn assays is the laboratorians’ role in closely scrutinizing proposed assays and defining their value in relation to available evidence. Analytical, as well as pre-analytical and post-analytical, aspects must be documented. In this review, we describe what laboratory professionals should
know about their cTn assay performance characteristics and the pre-analytical prerequisites for robustness to ensure optimal post-analytical reporting.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
cardiac troponin; highly sensitive assays; laboratory issues
Elenco autori:
M. Krintus, M. Panteghini
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