Enhancement of a pentacyclic tyrosine kinase inhibitor production in Cladosporium cf. cladosporioides by Cladosporol
Articolo
Data di Pubblicazione:
2006
Citazione:
Enhancement of a pentacyclic tyrosine kinase inhibitor production in Cladosporium cf. cladosporioides by Cladosporol / G.M. Assante, A. Bava, G. Nasini. - In: APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. - ISSN 0175-7598. - 69:6(2006), pp. 718-721. [10.1007/s00253-005-0054-2]
Abstract:
The binaphthyl derivative cladosporol A was
supplied from 60 to 200 mg l−1 to shaken cultures of Cladosporium cf. cladosporioides. Compared to blank, fungal
biomass was not affected by adding cladosporol till 100 mg l−1: it rather increased at higher ratios between 150
and 200 mg l−1. The production of the major pentacyclic metabolite 1, a cytokine production and tyrosine kinase inhibitor, was enhanced tenfold when cladosporol was
supplied at the highest ratio (200 mg l−1) to shaken growing cultures of the fungus. The bioconversion of cladosporol to cladosporol D through reductive cleavage of the epoxide group was also observed. Interest in this kind of metabolites lies in their potential activity vs DNA topoisomerase I.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
G.M. Assante, A. Bava, G. Nasini
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