Data di Pubblicazione:
2020
Citazione:
Potential statin drug interactions in elderly patients: a review / I. Damiani, A. Corsini, S. Bellosta. - In: EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. - ISSN 1742-5255. - (2020). [Epub ahead of print] [10.1080/17425255.2020.1822324]
Abstract:
Introduction: Persons aged more than 65 years may be more prone to suffer from chronic diseases and
comorbidities (as demonstrated by the recent COVID-19 pandemics) and are treated with multiple
concomitant medications. This may result in drug-drug interactions (DDIs) that are often overlooked in
clinical practice. Elderly patients are more affected by comorbidities increasing the risk of DDIs and
adverse drug reactions (ADRs). Statins are effective in elderly patients with or at risk for cardiovascular
disease (CVD) and are prescribed on a long-term basis and may undergo DDIs, particularly on pharmacokinetic
bases. The risk of DDIs varies among statins, and safety and ADRs of statins are of special
concern in patients affected by multiple chronic conditions requiring concomitant therapies at risk of
DDIs, such as the elderly.
Areas covered: The purpose of this manuscript is to give an update on the potential statin DDIs and
related ADRs with an exclusive focus on the data available in elderly patients.
Expert opinion: A better and more close attention to the potential DDIs among statins and other
therapeutic options will help physicians in selecting the more effective and less harmful treatment for
their patients. This is of importance, especially in older patients.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Aging; COVID-19; HIV patients; monoclonal antibodies; sacubitril; statin pharmacokinetics; tocilizumab;
Elenco autori:
I. Damiani, A. Corsini, S. Bellosta
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