Data di Pubblicazione:
2015
Citazione:
Peyronie's disease and autoimmunity-a real-life clinical study and comprehensive review / E. Ventimiglia, P. Capogrosso, M. Colicchia, L. Boeri, A. Serino, G. La Croce, A. Russo, U. Capitanio, A. Briganti, F. Cantiello, V. Mirone, R. Damiano, F. Montorsi, A. Salonia. - In: JOURNAL OF SEXUAL MEDICINE. - ISSN 1743-6095. - 12:4(2015), pp. 1062-1069. [10.1111/jsm.12825]
Abstract:
Introduction: Although heavily investigated over the last decades, Peyronie's disease (PD) pathogenesis remains unclear. Aim: We sought to investigate the association between PD and autoimmune diseases (ADs) in men seeking medical help for sexual dysfunction in the real-life setting. Methods: Complete sociodemographic and clinical data from a homogenous cohort of 1,140 consecutive Caucasian-European men were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index and ADs were stratified according to International Classification of Diseases, Ninth Revision classification. Main Outcome Measures: Descriptive statistics and multivariate logistic regression models tested the association between ADs and PD. Results: PD was diagnosed in 148 (13%) of the 1,140 men; of PD patients, 14 (9.5%) had a comorbid AD; conversely, the rate of ADs in non-PD patients was significantly lower (χ2=24.7; P<0.01). Both patient age and AD comorbidity achieved multivariable independent predictor status for PD (odds ratio [OR]: 1.05; P<0.01 and OR: 4.90; P<0.01, respectively). Conclusions: Our observational findings showed that ADs are highly comorbid with PD in a large cohort of same-race individuals seeking medical help for sexual dysfunction in the real-life setting. Ventimiglia E, Capogrosso P, Colicchia M, Boeri L, Serino A, La Croce G, Russo A, Capitanio U, Briganti A, Cantiello F, Mirone V, Damiano R, Montorsi F, and Salonia A. Peyronie's disease and autoimmunity-A real-life clinical study and comprehensive review. J Sex Med 2015;12:1062-1069.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Autoimmune Disease; Peyronie's Disease; Psoriasis; Sexual Dysfunction; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Autoimmune Diseases; Biomedical Research; Body Mass Index; Comorbidity; Health Behavior; Humans; Male; Middle Aged; Penile Induration; Retrospective Studies; Socioeconomic Factors; Young Adult
Elenco autori:
E. Ventimiglia, P. Capogrosso, M. Colicchia, L. Boeri, A. Serino, G. La Croce, A. Russo, U. Capitanio, A. Briganti, F. Cantiello, V. Mirone, R. Damiano, F. Montorsi, A. Salonia
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