Excitation function measurements for MN-52 production by deuteron beams irradiation for theranostic applications
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Data di Pubblicazione:
2020
Citazione:
Excitation function measurements for MN-52 production by deuteron beams irradiation for theranostic applications / S. Manenti, F. Bianchi, G. Hassan Harki, F. Groppi Garlandini. ((Intervento presentato al 10. convegno ICI : International Conference on Isotopes tenutosi a Kuala Lampur, Malaysia nel 2020.
Abstract:
Manganese-52 is a radionuclide which decays with positron emission and electron capture, with a medium-long half-life (T1/2 = 5.591 d). As a positron emitter, 52Mn has a possible and promising use in Nuclear Medicine as a radiotracer for PET diagnostic tests, useful to investigate biological and physiological processes occurring on the same time scale of its decay; the low energy of the positrons emitted (244.6 keV) and the short range in the tissues (0.63 mm) would allow to acquire diagnostic images of a quality similar to those obtained with radiotracers already in use, such as Fluorine-18 (252 keV; 0.66 mm). Moreover, the stable isotope of manganese Mn2+presents paramagnetic properties that make it suitable for use in MRI, opening the possibility of obtaining multi-modal PET / MEMRI images. Currently manganese is produced by irradiation with protons on chromium targets. We have studied the production by deuteron beams irradiation, that could be more advantageous.
Tipologia IRIS:
14 - Intervento a convegno non pubblicato
Keywords:
Mn-52; PET; MEMRI; deuterons; cyclotron
Elenco autori:
S. Manenti, F. Bianchi, G. Hassan Harki, F. Groppi Garlandini
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