An individual participant data meta-analysis on metabolomics profiles for obesity and insulin resistance in European children
Articolo
Data di Pubblicazione:
2019
Citazione:
An individual participant data meta-analysis on metabolomics profiles for obesity and insulin resistance in European children / C. Hellmuth, F.F. Kirchberg, S. Brandt, A. Moss, V. Walter, D. Rothenbacher, H. Brenner, V. Grote, D. Gruszfeld, P. Socha, R. Closa-Monasterolo, J. Escribano, V. Luque, E. Verduci, B. Mariani, J.-. Langhendries, P. Poncelet, J. Heinrich, I. Lehmann, M. Standl, O. Uhl, B. Koletzko, E. Thiering, M. Wabitsch. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 9:1(2019 Dec). [10.1038/s41598-019-41449-x]
Abstract:
Childhood obesity prevalence is rising in countries worldwide. A variety of etiologic factors contribute to childhood obesity but little is known about underlying biochemical mechanisms. We performed an individual participant meta-analysis including 1,020 pre-pubertal children from three European studies and investigated the associations of 285 metabolites measured by LC/MS-MS with BMI z-score, height, weight, HOMA, and lipoprotein concentrations. Seventeen metabolites were significantly associated with BMI z-score. Sphingomyelin (SM) 32:2 showed the strongest association with BMI z-score (P = 4.68 × 10 −23 ) and was also closely related to weight, and less strongly to height and LDL, but not to HOMA. Mass spectrometric analyses identified SM 32:2 as myristic acid containing SM d18:2/14:0. Thirty-five metabolites were significantly associated to HOMA index. Alanine showed the strongest positive association with HOMA (P = 9.77 × 10 −16 ), while acylcarnitines and non-esterified fatty acids were negatively associated with HOMA. SM d18:2/14:0 is a powerful marker for molecular changes in childhood obesity. Tracing back the origin of SM 32:2 to dietary source in combination with genetic predisposition will path the way for early intervention programs. Metabolic profiling might facilitate risk prediction and personalized interventions in overweight children.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
C. Hellmuth, F.F. Kirchberg, S. Brandt, A. Moss, V. Walter, D. Rothenbacher, H. Brenner, V. Grote, D. Gruszfeld, P. Socha, R. Closa-Monasterolo, J. Escribano, V. Luque, E. Verduci, B. Mariani, J.-. Langhendries, P. Poncelet, J. Heinrich, I. Lehmann, M. Standl, O. Uhl, B. Koletzko, E. Thiering, M. Wabitsch
Link alla scheda completa:
Link al Full Text: