Intracerebral Injection of Extracellular Vesicles from Mesenchymal Stem Cells Exerts Reduced Aβ Plaque Burden in Early Stages of a Preclinical Model of Alzheimer's Disease
Articolo
Data di Pubblicazione:
2019
Citazione:
Intracerebral Injection of Extracellular Vesicles from Mesenchymal Stem Cells Exerts Reduced Aβ Plaque Burden in Early Stages of a Preclinical Model of Alzheimer's Disease / C.A. Elia, M. Tamborini, M. Rasile, G. Desiato, S. Marchetti, P. Swuec, S. Mazzitelli, F. Clemente, A. Anselmo, M. Matteoli, M.L. Malosio, S. Coco. - In: CELLS. - ISSN 2073-4409. - 8:9(2019 Sep), pp. 1059.1-1059.20. [10.3390/cells8091059]
Abstract:
Bone marrow Mesenchymal Stem Cells (BM-MSCs), due to their strong protective and anti-inflammatory abilities, have been widely investigated in the context of several diseases for their possible therapeutic role, based on the release of a highly proactive secretome composed of soluble factors and Extracellular Vesicles (EVs). BM-MSC-EVs, in particular, convey many of the beneficial features of parental cells, including direct and indirect β-amyloid degrading-activities, immunoregulatory and neurotrophic abilities. Therefore, EVs represent an extremely attractive tool for therapeutic purposes in neurodegenerative diseases, including Alzheimer's disease (AD). We examined the therapeutic potential of BM-MSC-EVs injected intracerebrally into the neocortex of APPswe/PS1dE9 AD mice at 3 and 5 months of age, a time window in which the cognitive behavioral phenotype is not yet detectable or has just started to appear. We demonstrate that BM-MSC-EVs are effective at reducing the Aβ plaque burden and the amount of dystrophic neurites in both the cortex and hippocampus. The presence of Neprilysin on BM-MSC-EVs, opens the possibility of a direct β-amyloid degrading action. Our results indicate a potential role for BM-MSC-EVs already in the early stages of AD, suggesting the possibility of intervening before overt clinical manifestations.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
APPswe/PS1dE9 AD mice; Alzheimer’s disease; Aβ plaques; Neprilysin; SMI; bone marrow mesenchymal stem cells; dystrophic neuritis; extracellular vesicles
Elenco autori:
C.A. Elia, M. Tamborini, M. Rasile, G. Desiato, S. Marchetti, P. Swuec, S. Mazzitelli, F. Clemente, A. Anselmo, M. Matteoli, M.L. Malosio, S. Coco
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