Data di Pubblicazione:
2018
Citazione:
The Basolateral Amygdala Is Essential for Rapid Escape : A Human and Rodent Study / D. Terburg, D. Scheggia, R. Triana del Rio, F. Klumpers, A.C. Ciobanu, B. Morgan, E.R. Montoya, P.A. Bos, G. Giobellina, E.H. van den Burg, B. de Gelder, D.J. Stein, R. Stoop, J. van Honk. - In: CELL. - ISSN 0092-8674. - 175:3(2018 Oct), pp. 723-735. [10.1016/j.cell.2018.09.028]
Abstract:
Rodent research delineates how the basolateral amygdala (BLA) and central amygdala (CeA) control defensive behaviors, but translation of these findings to humans is needed. Here, we compare humans with natural-selective bilateral BLA lesions to rats with a chemogenetically silenced BLA. We find, across species, an essential role for the BLA in the selection of active escape over passive freezing during exposure to imminent yet escapable threat (Timm). In response to Timm, BLA-damaged humans showed increased startle potentiation and BLA-silenced rats demonstrated increased startle potentiation, freezing, and reduced escape behavior as compared to controls. Neuroimaging in humans suggested that the BLA reduces passive defensive responses by inhibiting the brainstem via the CeA. Indeed, Timm conditioning potentiated BLA projections onto an inhibitory CeA pathway, and pharmacological activation of this pathway rescued deficient Timm responses in BLA-silenced rats. Our data reveal how the BLA, via the CeA, adaptively regulates escape behavior from imminent threat and that this mechanism is evolutionary conserved across rodents and humans. Under conditions of imminent threat, by activating an inhibitory central amygdala pathway, the rodent and human basolateral amygdala play a key role in adaptively selecting and executing active escape responses rather than passive freezing behaviors.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
basolateral amygdala; central amygdala; DREADD; escape; fear; freezing; oxytocin; startle reflex; threat; Urbach Wiethe; Adult; Animals; Basolateral Nuclear Complex; Fear; Female; Freezing Reaction, Cataleptic; Humans; Male; Rats; Rats, Sprague-Dawley; Reflex, Startle; Species Specificity; Escape Reaction
Elenco autori:
D. Terburg, D. Scheggia, R. Triana del Rio, F. Klumpers, A.C. Ciobanu, B. Morgan, E.R. Montoya, P.A. Bos, G. Giobellina, E.H. van den Burg, B. de Gelder, D.J. Stein, R. Stoop, J. van Honk
Link alla scheda completa: