Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice
Articolo
Data di Pubblicazione:
2020
Citazione:
Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice / D. Scheggia, F. Managò, F. Maltese, S. Bruni, M. Nigro, D. Dautan, P. Latuske, G. Contarini, M. Gomez-Gonzalo, L. Requie, V. Ferretti, G. Castellani, D. Mauro, A. Bonavia, G. Carmignoto, O. Yizhar, P. Francesco. - In: NATURE NEUROSCIENCE. - ISSN 1097-6256. - 23:1(2020 Jan 16), pp. 47-60. [10.1038/s41593-019-0551-8]
Abstract:
The prefrontal cortex (PFC) is implicated in processing of the affective state of others through non-verbal communication. This social cognitive function is thought to rely on an intact cortical neuronal excitatory and inhibitory balance. Here combining in vivo electrophysiology with a behavioral task for affective state discrimination in mice, we show a differential activation of medial PFC (mPFC) neurons during social exploration that depends on the affective state of the conspecific. Optogenetic manipulations revealed a double dissociation between the role of interneurons in social cognition. Specifically, inhibition of mPFC somatostatin (SOM+), but not of parvalbumin (PV+ ) interneurons, abolishes affective state discrimination. Accordingly, synchronized activation of mPFC SOM+ interneurons selectively induces social discrimination. As visualized by in vivo single-cell microendoscopic Ca2+ imaging, an increased synchronous activity of mPFC SOM+ interneurons, guiding inhibition of pyramidal neurons, is associated with affective state discrimination. Our findings provide new insights into the neurobiological mechanisms of affective state discrimination.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
social cognition, prefrontal cortex, somatostatin, parvalbumin, brain circuits, ontogenetica
Elenco autori:
D. Scheggia, F. Managò, F. Maltese, S. Bruni, M. Nigro, D. Dautan, P. Latuske, G. Contarini, M. Gomez-Gonzalo, L. Requie, V. Ferretti, G. Castellani, D. Mauro, A. Bonavia, G. Carmignoto, O. Yizhar, P. Francesco
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