MRI relaxation properties of water-soluble apoferritin-encapsulated gadolinium oxide-hydroxide nanoparticles
Articolo
Data di Pubblicazione:
2009
Citazione:
MRI relaxation properties of water-soluble apoferritin-encapsulated gadolinium oxide-hydroxide nanoparticles / P. Sánchez, E. Valero, N.Gálvez, J.M. Domínguez-Vera, M. Marinone, G. Poletti, M. Corti, A. Lascialfari. - In: DALTON TRANSACTIONS. - ISSN 1477-9226. - 5:5(2009), pp. 800-804. [10.1039/b809645g]
Abstract:
We have prepared water-soluble gadolinium oxide nanoparticles that show potential as MRI contrast agents. The particles were built into the apoferritin cavity and have an average size of 5 nm. After seven days a loss of 5% of Gd was detected compared with the as-prepared samples; after that the Gd remained constant and stabilized inside the apoferritin, indicating that the apoferritin capsid acts as a Gd store, avoiding metal delivery and consequent toxicity. The NMR longitudinal and transverse relaxivities resulted about 10 and 70 times higher than the ones of clinically approved paramagnetic Gd-chelates, thus indicating the possible route for synthesizing a novel class of MRI contrast agents.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
P. Sánchez, E. Valero, N. Gálvez, J.M. Domínguez Vera, M. Marinone, G. Poletti, M. Corti, A. Lascialfari
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