Allylation of isatin-derived N-Boc-hydrazones followed by Pd-catalyzed carboamination reaction: An entry to 3-spiro-pyrazolidyl-oxindoles
Articolo
Data di Pubblicazione:
2019
Citazione:
Allylation of isatin-derived N-Boc-hydrazones followed by Pd-catalyzed carboamination reaction: An entry to 3-spiro-pyrazolidyl-oxindoles / S. Gazzotti, M. Manenti, L. Lo Presti, A. Silvani. - In: RSC ADVANCES. - ISSN 2046-2069. - 9:65(2019 Nov 20), pp. 37788-37800. [10.1039/c9ra07712j]
Abstract:
The indium-mediated allylation of novel 3-(2-Boc-hydrazono)indolin-2-one derivatives, followed by a palladium-catalysed carboamination reaction, is described to afford unprecedented spirocyclic oxindoles in good yields. The method provides an efficient access to both cis and trans diastereoisomers of highly functionalized compounds, bearing an N-Boc, 5-substituted pyrazolidine ring at the C3-oxindole spiro junction. The versatility of the method is fully demonstrated starting from a series of substituted isatins and employing a variety of aryl halides in the key cyclization step.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
S. Gazzotti, M. Manenti, L. Lo Presti, A. Silvani
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