A non-steroidal gametic factor linked to DNA modulates δ-aminolevulinic acid synthase inducibility acting on liver transcriptional and translational processes
Articolo
Data di Pubblicazione:
1982
Citazione:
A non-steroidal gametic factor linked to DNA modulates δ-aminolevulinic acid synthase inducibility acting on liver transcriptional and translational processes / G. Lugaro, E. Manera, M.M. Casellato, L. Riboni. - In: EXPERIMENTAL GERONTOLOGY. - ISSN 0531-5565. - 17:5(1982), pp. 365-373. [10.1016/0531-5565(82)90036-5]
Abstract:
The effect of an acidic factor of low molecular weight (about 1,000 daltons), extracted from bovine spermatozoan DNA, on the inducibility of δ-aminolevulinic acid synthase by ethanol during aging in rat has been examined. The increased enzyme inducibility in 600-day old rats is supported by stimulation of transcriptional and translational processes; on the contrary, in 30-day old rats, the higher enzyme values induced by ethanol are significantly decreased after factor treatment. The active factor is strongly DNA-bound in the native spermatozoan DNA. This would imply a possible role in regulating gene expression in vivo.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
G. Lugaro, E. Manera, M.M. Casellato, L. Riboni
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