Data di Pubblicazione:
2018
Citazione:
A simplified method to analyze cardiopulmonary exercise test / C. Carriere, U. Corrà, M. Piepoli, A. Bonomi, M. Merlo, S. Barbieri, E. Salvioni, S. Binno, M. Mapelli, F. Righini, F. De Martino, S. Sciomer, C. Vignati, F. Moscucci, F. Veglia, G. Sinagra, P. Agostoni. ((Intervento presentato al 79. convegno Congresso Società Italiana di Cardiologia (SIC) tenutosi a Roma nel 2018.
Abstract:
Background:
We evaluated the prognostic meaning of the simple presence or absence of identifiable anaerobic
threshold (AT) and respiratory compensation point (RCP) at cardiopulmonary exercise tests
(CPETs) performed with a maximal incremental exercise protocol.
Methods:
In the present multicenter study, we retrospectively analyzed data in 1,995 patients with heart
failure with reduced ejection fraction (HFrEF). All underwent clinical and laboratory evaluation,
echocardiography, and maximal CPET at baseline. The analysis was performed according to
absence of identified AT and RCP (group 1: n = 292; 15%), presence of AT but absence of
identified RCP (group 2: n = 920; 46%), and presence of both AT and RCP (group 3: n = 783;
39%). The study end point was the composite of cardiovascular mortality, urgent heart transplant,
and left ventricular assist device implantation.
Results:
Median follow-up was 2.97 years (interquartile range, 1.50-5.35 years). Eighty-seven (30%), 169
(18%), and 111 (14%) events were observed in groups 1, 2, and 3, respectively (P = .025).
Compared with results in group 3 (patients with the best survival), the likelihood of reaching the
study end point increased 2.7 times when neither AT nor RCP were identified (hazard ratio, 2.74)
and 1.4 times when only AT was identified (hazard ratio, 1.4). Moreover, adding the presence or
absence of identified AT and RCP improved the prognostic power of peak oxygen uptake
because a significant reclassification was obtained.
Conclusions:
AT and RCP identification has a potential role in the prognostic stratification of HFrEF.
Tipologia IRIS:
14 - Intervento a convegno non pubblicato
Elenco autori:
C. Carriere, U. Corrà, M. Piepoli, A. Bonomi, M. Merlo, S. Barbieri, E. Salvioni, S. Binno, M. Mapelli, F. Righini, F. De Martino, S. Sciomer, C. Vignati, F. Moscucci, F. Veglia, G. Sinagra, P. Agostoni
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