Data di Pubblicazione:
2005
Citazione:
Structure-function relationships in the growing hexa-coordinate globin sub-family / A. Pesce, D. de Sanctis, M. Nardini, M. Bolognesi - In: MMD-meeting workbook: Poster Session / CNR-INFM. - [s.l] : CNR-INFM, 2005. - pp. 267-267 (( convegno MMD Meeting, Matter, Materials and Devices tenutosi a Genova nel 2005.
Abstract:
Hemoglobin and related heme proteins reversibly
bind gaseus diatomic ligands (O2,
NO, CO) to a penta-coordinate heme Fe atom,
the ligand filling the sixth coordination site.
Several new globins have recently been reported
to display a functionally-relevant hexacoordinate
(6C) heme Fe atom, whose sixth
coordination site is filled by an endogenous
His protein ligand. The reversible intramolecular
hexa- to penta-coordination process at the
heme-Fe atom modulates O2, NO, CO ligand
binding properties of 6C-globins. Here, we
present the results of three-year investigations
carried over in our lab on the crystal structures
of 6C-hemoglobins from human brain, human
tissues, and from Drosophila. Mechanisms for
6C-5C transitions are discussed on structural
grounds.
Tipologia IRIS:
03 - Contributo in volume
Elenco autori:
A. Pesce, D. de Sanctis, M. Nardini, M. Bolognesi
Link alla scheda completa:
Titolo del libro:
MMD-meeting workbook: Poster Session