Data di Pubblicazione:
2011
Citazione:
Lymphangioleiomyomatosis: What do we know and what are we looking for? / S. Harari, O. Torre, J. Moss. - In: EUROPEAN RESPIRATORY REVIEW. - ISSN 0905-9180. - 20:119(2011), pp. 34-44. [10.1183/09059180.00011010]
Abstract:
Lymphangioleiomyomatosis (LAM) is a rare disease characterised by proliferation of abnormal smooth muscle-like cells (LAM cells) leading to progressive cystic destruction of the lung, lymphatic abnormalities and abdominal tumours. It affects predominantly females and can occur sporadically or in patients with tuberous sclerosis complex. This review describes the recent progress in our understanding of the molecular pathogenesis of the disease and LAM cell biology. It also summarises current therapeutic approaches and the most promising areas of research for future therapeutic strategies.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
LAM cells; Lymphangioleiomyomatosis; Tuberous sclerosis complex
Elenco autori:
S. Harari, O. Torre, J. Moss
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