The gut microbiota affects host pathophysiology as an endocrine organ : a focus on cardiovascular disease
Articolo
Data di Pubblicazione:
2020
Citazione:
The gut microbiota affects host pathophysiology as an endocrine organ : a focus on cardiovascular disease / M. Busnelli, S. Manzini, G. Chiesa. - In: NUTRIENTS. - ISSN 2072-6643. - 12:1(2020 Jan), pp. 79.1-79.32. [10.3390/nu12010079]
Abstract:
It is widely recognized that the microorganisms inhabiting our gastrointestinal tract—the gut microbiota—deeply affect the pathophysiology of the host. Gut microbiota composition is mostly modulated by diet, and gut microorganisms communicate with the different organs and tissues of the human host by synthesizing hormones and regulating their release. Herein, we will provide an updated review on the most important classes of gut microbiota-derived hormones and their sensing by host receptors, critically discussing their impact on host physiology. Additionally, the debated interplay between microbial hormones and the development of cardiovascular disease will be thoroughly analysed and discussed.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Atherosclerosis; Bile acids; Cardiovascular disease; Gut microbiota; Hormones; Metabolism; Neurohormones; SCFA
Elenco autori:
M. Busnelli, S. Manzini, G. Chiesa
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