Light up ADHD : II. Neuropharmacological effects measured by near infrared spectroscopy : is there a biomarker?
Articolo
Data di Pubblicazione:
2019
Citazione:
Light up ADHD : II. Neuropharmacological effects measured by near infrared spectroscopy : is there a biomarker? / S. Grazioli, M. Mauri, A. Crippa, E. Maggioni, M. Molteni, P. Brambilla, M. Nobile. - In: JOURNAL OF AFFECTIVE DISORDERS. - ISSN 0165-0327. - 244(2019), pp. 100-106. [10.1016/j.jad.2018.10.100]
Abstract:
Background: Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by deficits in self-controlling attention, behavior, and emotions. In recent years, noninvasive optical techniques, such as near infrared spectroscopy (NIRS), have been used to measure the neural correlates of pharmacological-therapy outcomes in children and adolescents with ADHD. Methods: We reviewed a short series of articles that investigated the results of functional NIRS (fNIRS) on developmental-age ADHD. The review was limited to fNIRS studies that investigated the cortical responses that occurred during neuropsychological tasks in ADHD patients who received methylphenidate or atomoxetine. Results: The majority of the reviewed studies revealed the presence of increased oxygenated hemoglobin concentrations in the prefrontal cortex following pharmacotherapy in ADHD samples. A higher frequency of right-lateralized results was found. Limitations: The considered studies are characterized by substantial methodological heterogeneity in terms of the patients’ medication status and washout period, explored cerebral regions, and neuropsychological tasks. Conclusions: fNIRS seems to be a promising tool for the detection of pharmacological-treatment biomarkers in samples of children and adolescents with ADHD.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
ADHD; Biomarker; fNIRS; Pharmachological-treatment; Rehabilitation; Aging; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Biomarkers; Humans; Methylphenidate; Oxyhemoglobins; Prefrontal Cortex; Spectroscopy, Near-Infrared
Elenco autori:
S. Grazioli, M. Mauri, A. Crippa, E. Maggioni, M. Molteni, P. Brambilla, M. Nobile
Link alla scheda completa: