Benzodioxane‐Benzamides as Antibacterial Agents : Computational and SAR Studies to Evaluate the Influence of the 7‐Substitution in FtsZ Interaction
Articolo
Data di Pubblicazione:
2019
Citazione:
Benzodioxane‐Benzamides as Antibacterial Agents : Computational and SAR Studies to Evaluate the Influence of the 7‐Substitution in FtsZ Interaction / V. Straniero, V. Sebastián‐Pérez, M. Hrast, C. Zanotto, A. Casiraghi, L. Suigo, I. Zdovc, A. Radaelli, C. De Giuli Morghen, E. Valoti. - In: CHEMMEDCHEM. - ISSN 1860-7187. - (2019 Nov 21). [Epub ahead of print]
Abstract:
FtsZ is a crucial prokaryotic protein involved in bacterial cell replication. It recently arose as a promising target in the search for antimicrobial agents able to fight antimicrobial resistance. In this work, going on with our structure‐activity relationship (SAR) study, we developed variously 7‐substituted 1,4‐benzodioxane compounds, linked to the 2,6‐difluorobenzamide by a methylenoxy bridge. Compounds exhibit promising antibacterial activities not only against multidrug‐resistant Staphylococcus aureus, but also on mutated Escherichia coli strains, thus enlarging their spectrum of action toward Gram‐negative bacteria as well. Computational studies elucidated, through a validated FtsZ binding protocol, the structural features of new promising derivatives as FtsZ inhibitors.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
FtsZinhibition; 1,4-benzodioxane-2,6-difluorobenzamide; Mutated E. coli; molecular modelling; cavitydetection
Elenco autori:
V. Straniero, V. Sebastián‐Pérez, M. Hrast, C. Zanotto, A. Casiraghi, L. Suigo, I. Zdovc, A. Radaelli, C. De Giuli Morghen, E. Valoti
Link alla scheda completa: