Data di Pubblicazione:
2004
Citazione:
Properties of theophylline tablets powder-coated with methacrylate ester copolymers / W. Zheng, M. Cerea, D. Sauer, J.W. McGinity. - In: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY. - ISSN 1773-2247. - 14:4(2004), pp. 319-325.
Abstract:
The purpose of this paper is to characterize the physiochemical and dissolution properties of tablets coated using a novel, solvent-free powder coating process. The ammonio methacrylate copolymers, Eudragit RS PO and Eudragit RL PO (95:5), were pre-plasticized by a hot-melt extrasion process using a plasticizer and thermal lubricant, and then cryogenically ground into a fine powder. The powder coating process involved three steps including priming, powder layering and curing. The use of a solid primer at the initial stage of powder coating increased the adhesion of the pre-plasticized acrylic polymers to the substrates. At 8% w/w total weight gain, immediate release theophylline tablets that were powder-coated with Eudragit RS PO/RL PO demonstrated a 12-h sustained release profile. The theophylline release rate of powder-coated tablets was significantly influenced by the curing temperature, plasticizer concentration, coating level and particle size of the coating powder. Eudragit RS PO/RL PO powder-coated tablets demonstrated a stable drug release profile after 3-month storage at 25°C/60% RH and 40°C/75%RH. This novel powder coating process was demonstrated to be an efficient coating method to produce stable sustained release dosage forms.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cryogenic grinding; Eudragit RS PO/RL PO; Hot-melt extrusion; Powder coating; Tablets
Elenco autori:
W. Zheng, M. Cerea, D. Sauer, J.W. McGinity
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