Differential prevalence and demographic and clinical correlates of antidepressant use in American bipolar I versus bipolar II disorder patients
Articolo
Data di Pubblicazione:
2018
Citazione:
Differential prevalence and demographic and clinical correlates of antidepressant use in American bipolar I versus bipolar II disorder patients / F. Hooshmand, D. Do, S. Shah, A. Gershon, D.Y. Park, H. Kim, L.D. Yuen, B. Dell'Osso, P.W. Wang, T.A. Ketter, S. Miller. - In: JOURNAL OF AFFECTIVE DISORDERS. - ISSN 0165-0327. - 234(2018), pp. 74-79. [10.1016/j.jad.2018.02.091]
Abstract:
Aims: Antidepressant use is controversial in bipolar disorder (BD) due to questionable efficacy/psychiatric tolerability. We assessed demographic/clinical characteristics of baseline antidepressant use in BD patients. Methods: Prevalence and correlates of baseline antidepressant use in 503 BD I and BD II outpatients referred to the Stanford Bipolar Clinic during 2000–2011 were assessed with the Systematic Treatment Enhancement Program for BD (STEP-BD) Affective Disorders Evaluation. Results: Antidepressant use was 39.0%, overall, and was higher in BD II versus BD I (46.9% versus 30.5%, p = 0.0002). Both BD I and BD II antidepressant compared to non-antidepressant users had higher rates of complex pharmacotherapy (≥ 4 mood stabilizers, antipsychotics, and/or antidepressants) and use of other psychotropics. Antidepressant use in BD II versus BD I was higher during euthymia (44.0% vs. 28.0%) and subsyndromal symptoms (56.1% vs. 28.6%), but not depression or mood elevation. Limitations: American tertiary BD clinic referral sample receiving open naturalistic treatment. Conclusions: In our sample, antidepressant use was higher in BD II versus BD I patients, and was associated with markers of heightened illness severity in both BD I and BD II patients. Additional research is warranted to investigate these complex relationships.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Antidepressant; Bipolar disorder; Illness characteristics; Adult; Antidepressive Agents; Bipolar Disorder; Demography; Female; Humans; Male; Outpatients; Patient Preference; United States
Elenco autori:
F. Hooshmand, D. Do, S. Shah, A. Gershon, D.Y. Park, H. Kim, L.D. Yuen, B. Dell'Osso, P.W. Wang, T.A. Ketter, S. Miller
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