Liver and intestinal protective effects of Castanea sativa Mill. bark extract in high-fat diet rats
Articolo
Data di Pubblicazione:
2018
Citazione:
Liver and intestinal protective effects of Castanea sativa Mill. bark extract in high-fat diet rats / R. Budriesi, F. Vivarelli, D. Canistro, R. Aldini, C.B. Marquillas, I. Corazza, R. Fato, S. Cirillo, C. Bergamini, A. D'Errico, C. Bolchi, M. Cevenini, A. Degiovanni, M. Frosini, L. Camarda, A. Chiarini, M. Micucci. - In: PLOS ONE. - ISSN 1932-6203. - 13:8(2018 Aug), pp. e0201540.1-e0201540.19. [10.1371/journal.pone.0201540]
Abstract:
The effects of Castanea sativa Mill. have been studied in high fat diet (HFD) overweight rats. Natural Extract of Chestnut bark (Castanea sativa Mill.) (ENC®), rich in ellagitannins, has been studied in 120 male Sprague-Dawley rats, divided in four groups. Two groups were controls: regular (RD) and HDF diet. Two groups received ENC® (20 mg/kg/day): RD + ENC® and HFD + ENC®. At baseline and at 7, 14 and 21 days, weight gain, serum lipids, plasma cytokines, liver histology, microsomial enzymes and oxidation, intestinal oxidative stress and contractility were studied. HFD increased body weight, increased pro-inflammatory cytokines, induced hepatocytes microvescicular steatosis, altered microsomial, increased liver and intestinal oxidative stress, deranged intestinal contractility. In HFD-fed rats, ENC® exerted antiadipose and antioxidative activities and normalized intestinal contractility, suggesting a potential approach to overweight management associated diseases.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Animals; Diet, High-Fat; Disease Models, Animal; Fagaceae; Gastrointestinal Motility; Humans; Intestinal Mucosa; Liver; Male; Obesity; Oxidative Stress; Plant Bark; Plant Extracts; Protective Agents; Rats; Rats, Sprague-Dawley; Treatment Outcome; Weight Gain
Elenco autori:
R. Budriesi, F. Vivarelli, D. Canistro, R. Aldini, C.B. Marquillas, I. Corazza, R. Fato, S. Cirillo, C. Bergamini, A. D'Errico, C. Bolchi, M. Cevenini, A. Degiovanni, M. Frosini, L. Camarda, A. Chiarini, M. Micucci
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