Biological variability of albumin excretion rate and albumin to creatinine ratio in hypertensive type 2 diabetic patients
Articolo
Data di Pubblicazione:
2003
Citazione:
Biological variability of albumin excretion rate and albumin to creatinine ratio in hypertensive type 2 diabetic patients / A. Mosca, R. Paleari, F. Ceriotti, A. Lapolla, D. Fedele. - In: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. - ISSN 1434-6621. - 41:9(2003 Sep), pp. 1229-1233.
Abstract:
The importance of measuring microalbuminuria is well established. However, only scanty data are available concerning the biological variability of albumin excretion in type 2 diabetic subjects. We report our experience from a large clinical trial of a new antihypertensive drug (Lercanidipine) designed to reduce albumin excretion and blood pressure in type 2 diabetic patients with hypertension and microalbuminuria. Eighty seven patients with persistent microalbuminuria were studied within 1 year of the clinical trial. The measurements were performed on blood and timed urine samples frozen at -80°C and shipped to a central laboratory unit. Preliminary experiments were performed to assess albumin stability in urine under various conditions (4°C -20°C and -80°C), particularly with regard to the albumin/creatinine ratio. Urine samples can be stored up to 3 weeks at 4°C or up to 2 months at -80°C. The biological variability of the albumin excretion rate was 25.7%, while that of the albumin/creatinine ratio was 13.4%. These data are useful in defining the analytical goals of imprecision for microalbuminuria (CV = 13% for albumin, and CV = 6% for albumin/creatinine ratio). No correlation between albumin/creatinine ratio and HbA1c was found in the cohort of 61 microalbuminuric patients who completed the trial. The results of this study confirm that the albumin/creatinine ratio is much more suitable for monitoring albumin excretion in longitudinal studies than the albumin excretion rate.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
A. Mosca, R. Paleari, F. Ceriotti, A. Lapolla, D. Fedele
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