Exploring calixarene-based clusters for efficient functional presentation of Streptococcus pneumoniae saccharides
Articolo
Data di Pubblicazione:
2019
Citazione:
Exploring calixarene-based clusters for efficient functional presentation of Streptococcus pneumoniae saccharides / M. Giuliani, F. Faroldi, L. Morelli, E. Torre, G. Lombardi, S. Fallarini, F. Sansone, F. Compostella. - In: BIOORGANIC CHEMISTRY. - ISSN 0045-2068. - 93(2019 Dec).
Abstract:
Calixarenes are promising scaffolds for an efficient clustered exposition of multiple saccharide antigenic units. Herein we report the synthesis and biological evaluation of a calix[6]arene functionalized with six copies of the trisaccharide repeating unit of Streptococcus pneumoniae (SP) serotype 19F. This system has demonstrated its ability to efficiently inhibit the binding between the native 19F capsular polysaccharide and anti-19F antibodies, despite a low number of exposed saccharide antigens, well mimicking the epitope presentations in the polysaccharide. The calix[6]arene mobile scaffold has been selected for functionalization with SP 19F repeating unit after a preliminary screening of four model glycocalixarenes, functionalized with N-acetyl mannosamine, and differing in the valency and/or conformational properties. This work is a step forward towards the development of new fully synthetic calixarenes comprising small carbohydrate antigens as potential carbohydrate-based vaccine scaffolds.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Calixarenes; Multivalent ligands; Saccharide antigens; Serotype 19F; Streptococcus pneumoniae
Elenco autori:
M. Giuliani, F. Faroldi, L. Morelli, E. Torre, G. Lombardi, S. Fallarini, F. Sansone, F. Compostella
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