Circadian rhythm of COPD symptoms in clinically based phenotypes: Results from the STORICO Italian observational study
Articolo
Data di Pubblicazione:
2019
Citazione:
Circadian rhythm of COPD symptoms in clinically based phenotypes: Results from the STORICO Italian observational study / N. Scichilone, R. Antonelli Incalzi, F. Blasi, P. Schino, G. Cuttitta, A. Zullo, A. Ori, G.W. Canonica, M.P. Foschino, R. Prediletto, C.M.E. Tranfa, M.C. Zappa, P. Patriciello, L. Labate, S. Mariotta, S. Nava, A. Vatrella, M. Mastroberardino, R. Sarzani, A. Iuliano, L. Maggi, A. Zedda, A. Pesci, G. Sera, A. Nicolini, S.W. Di Donato, S. Forte, M. Del Donno, F. Rivolta, M. Ferliga, A.F. Raco, L. Di Re, G. Cabibbo, R. Maselli, C. Gulotta, S. Nardini, E.E. Guffanti, W. Castellani, L. Triolo, G. Passalacqua, B. Beghè, S. Lo Cicero, E. Faccini, E. Atzeni, R. Tazza, P. Giamesio. - In: BMC PULMONARY MEDICINE. - ISSN 1471-2466. - 19:1(2019 Sep 09).
Abstract:
Background: Chronic Obstructive Pulmonary Disease (COPD) encompasses various phenotypes that severely limit
the applicability of precision respiratory medicine. The present investigation is aimed to assess the circadian rhythm
of symptoms in pre-defined clinical COPD phenotypes and its association with health-related quality of life (HRQoL), the quality of sleep and the level of depression/anxiety in each clinical phenotype.
Methods: The STORICO (NCT03105999) Italian observational prospective cohort study enrolled COPD subjects. A
clinical diagnosis of either chronic bronchitis (CB), emphysema (EM) or mixed COPD-asthma (MCA) phenotype was
made by clinicians at enrollment. Baseline early-morning, day-time and nocturnal symptoms (gathered via the
Night-time, Morning and Day-time Symptoms of COPD questionnaire), HR-QoL (via the St. George’s Respiratory
Questionnaire), anxiety and depression levels (via the Hospital Anxiety and Depression Scale), quality of sleep (via
COPD and Asthma Sleep Impact Scale), physical activity (via the International Physical Activity Questionnaire) as well as
lung function were recorded.
Results: 606 COPD subjects (age 71.4 ± 8.2 years, male 75.1%) were studied. 57.9, 35.5 5.3 and 1.3% of the sample
belonged to the CB, EM, MCA and EM + CB phenotypes respectively. The vast majority of subjects reported earlymorning and day-time symptoms (79.5 and 79.2% in the CB and 75.8 and 77.7% in the EM groups); the proportion
suffering from night-time symptoms was higher in the CB than in the EM group (53.6% vs. 39.5%, p = 0.0016). In
both CB and EM, indiscriminately, the presence of symptoms during the 24-h day was associated with poorer HRQoL, worse quality of sleep and higher levels of anxiety/depression.
Conclusions: The findings highlight the primary classificatory role of nocturnal symptoms in COPD.
Trial registration: Trial registration number: NCT03105999, date of registration: 10th April 2017.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
24-hour symptoms; Clinical phenotype; Respiratory function; Real-world
Elenco autori:
N. Scichilone, R. Antonelli Incalzi, F. Blasi, P. Schino, G. Cuttitta, A. Zullo, A. Ori, G.W. Canonica, M.P. Foschino, R. Prediletto, C.M.E. Tranfa, M.C. Zappa, P. Patriciello, L. Labate, S. Mariotta, S. Nava, A. Vatrella, M. Mastroberardino, R. Sarzani, A. Iuliano, L. Maggi, A. Zedda, A. Pesci, G. Sera, A. Nicolini, S.W. Di Donato, S. Forte, M. Del Donno, F. Rivolta, M. Ferliga, A.F. Raco, L. Di Re, G. Cabibbo, R. Maselli, C. Gulotta, S. Nardini, E.E. Guffanti, W. Castellani, L. Triolo, G. Passalacqua, B. Beghè, S. Lo Cicero, E. Faccini, E. Atzeni, R. Tazza, P. Giamesio
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