Quality of life and seizure control in patients with brain tumor-related epilepsy treated with levetiracetam monotherapy : preliminary data of an open-label study
Articolo
Data di Pubblicazione:
2009
Citazione:
Quality of life and seizure control in patients with brain tumor-related epilepsy treated with levetiracetam monotherapy : preliminary data of an open-label study / L. Dinapoli, M. Maschio, B. Jandolo, A. Fabi, A. Pace, F. Sperati, P. Muti. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 30:4(2009), pp. 353-359.
Abstract:
The aim of this pilot study was to investigate the effects of levetiracetam monotherapy on seizure control, quality of life and neurocognitive performance in patients with brain tumor-related epilepsy. We present here preliminary data from 18 patients with follow-up of 6 months. We evaluated seizure frequency at baseline. We used administered Mini Mental State Examination (MMSE), Karnofsky Performance Status (KPS), Barthel index (BI), QOLIE 31P (V2), EORTC QLQ-C30 and Adverse Events Profile. After 6 months, 16 patients were seizure free (88.9%), 2 (11.1%) had reduction in seizure frequency >50%. Compared to baseline, we observed a worsening of performance (KPS p = 0.011; BI = 0.008) and global lower cognitive performance (MMSE p = 0.011); distress related to seizure frequency (p = 0.003) and medication effects (p = 0.046) were significantly lower. Levetiracetam caused mild and reversible side effects. These preliminary data on LEV monotherapy in patients with brain tumor-related epilepsy show that this antiepileptic drug is efficacious and well tolerated.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Brain tumor-related epilepsy; Efficacy; Levetiracetam; Quality of life; Activities of Daily Living; Adult; Aged; Anticonvulsants; Blood Cell Count; Brain Neoplasms; Combined Modality Therapy; Epilepsy; Female; Humans; Karnofsky Performance Status; Levetiracetam; Logistic Models; Male; Middle Aged; Neuropsychological Tests; Personal Autonomy; Piracetam; Seizures; Surveys and Questionnaires; Young Adult; Quality of Life
Elenco autori:
L. Dinapoli, M. Maschio, B. Jandolo, A. Fabi, A. Pace, F. Sperati, P. Muti
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