Amphiphilic N-glycosyl-thiocarbamoyl cyclodextrins: synthesis, selfassembly and fluorimetry of recognition by Lens culinaris lectin.
Articolo
Data di Pubblicazione:
2007
Citazione:
Amphiphilic N-glycosyl-thiocarbamoyl cyclodextrins: synthesis, selfassembly and fluorimetry of recognition by Lens culinaris lectin / S. McNicholas, A. Rencurosi, L. Lay, A. Mazzaglia, L. Sturiale, M. Perez, R. Darcy. - In: BIOMACROMOLECULES. - ISSN 1525-7797. - 8:6(2007), pp. 1851-1857.
Abstract:
Amphiphilic alpha-cyclodextrins have been synthesized bearing hexylthio, dodecylthio, and hexadecylthio chains at
the 6-positions and glycosylthiocarbamoyl-oligo(ethylene glycol) units at the 2-positions. The glycosyl residues
(alpha-D-mannosyl and beta-L-fucosyl) are intended for cell-targeting. Self-assembly of these new amphiphilic glycosylated
cyclodextrins in water to form vesicles was investigated by dynamic light scattering and transmission electron
microscopy. Selective binding of the hexylthio assemblies to a protein receptor (Lens culinaris lectin) was confirmed
by fluorescence spectroscopy.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
S. McNicholas, A. Rencurosi, L. Lay, A. Mazzaglia, L. Sturiale, M. Perez, R. Darcy
Link alla scheda completa: