A two-dimensional coordination compound as a zinc ion selective luminescent probe for biological applications
Articolo
Data di Pubblicazione:
2007
Citazione:
A two-dimensional coordination compound as a zinc ion selective luminescent probe for biological applications / K. Dhara, S. Karan, J. Ratha, P. Roy, G. Chandra, M. Manassero, B. Mallik, P. Banerjee. - In: CHEMISTRY - AN ASIAN JOURNAL. - ISSN 1861-4728. - 2:9(2007), pp. 1091-1100.
Abstract:
A 2D coordination compound {[Cu2(HL)(N3)]ClO4} (1; H3L=2,6-bis(hydroxyethyliminoethyl)-4-methyl phenol) was synthesized and characterized by single-crystal X-ray diffraction to be a polymer in the crystalline state. Each [Cu2(HL)(N3)]+ species is connected to its adjacent unit by a bridging alkoxide oxygen atom of the ligand to form a helical propagation along the crystallographic a axis. The adjacent helical frameworks are connected by a ligand alcoholic oxygen atom along the crystallographic b axis to produce pleated 2D sheets. In solution, 1 dissociates into [Cu2(HL)2(H3L)]2H2O (2); the monomer displays high selectivity for Zn2+ and can be used in HEPES buffer (pH 7.4) as a zinc ion selective luminescent probe for biological application. The system shows a nearly 19-fold Zn2+-selective chelation-enhanced fluorescence response in the working buffer. Application of 2 to cultured living cells (B16F10 mouse melanoma and A375 human melanoma) and rat hippocampal slices was also studied by fluorescence microscopy.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
biosensors ; copper ; fluorescent probes ; luminescence ; zinc sensors
Elenco autori:
K. Dhara, S. Karan, J. Ratha, P. Roy, G. Chandra, M. Manassero, B. Mallik, P. Banerjee
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