Data di Pubblicazione:
2018
Citazione:
MicroRNA-128-3p-mediated depletion of Drosha promotes lung cancer cell migration / T. Frixa, A. Sacconi, M. Cioce, G. Roscilli, F.F. Ferrara, L. Aurisicchio, C. Pulito, S. Telera, M. Carosi, P. Muti, S. Strano, S. Donzelli, G. Blandino. - In: CARCINOGENESIS. - ISSN 0143-3334. - 39:2(2018 Feb), pp. 293-304. [10.1093/carcin/bgx134]
Abstract:
Alteration in microRNAs (miRNAs) expression is a frequent finding in human cancers. In particular, widespread miRNAs down-regulation is a hallmark of malignant transformation. In the present report, we showed that the miR-128-3p, which is up-regulated in lung cancer tissues, has Drosha and Dicer, two key enzymes of miRNAs processing, as the main modulation targets leading to the widespread down-regulation of miRNA expression. We observed that the miRNAs downregulation induced by miR-128-3p contributed to the tumorigenic properties of lung cancer cells. In particular, miR- 128-3p-mediated miRNAs down-regulation contributed to aberrant SNAIL and ZEB1 expression thereby promoting the epithelial-to-mesenchymal transition (EMT) program. Drosha also resulted to be implicated in the control of migratory phenotype as its expression counteracted miR-128-3p functional effects. Our study provides mechanistic insights into the function of miR-128-3p as a key regulator of the malignant phenotype of lung cancer cells. This also enforces the remarkable impact of Drosha and Dicer alteration in cancer, and in particular it highlights a role for Drosha in non-smallcell lung cancer cells migration.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
adenocarcinoma; adenocarcinoma of lung; cell line, tumor; cell movement; disease-free survival; gene expression regulation, neoplastic; humans; Kaplan-Meier estimate; lung neoplasms; microRNAs; ribonuclease III
Elenco autori:
T. Frixa, A. Sacconi, M. Cioce, G. Roscilli, F.F. Ferrara, L. Aurisicchio, C. Pulito, S. Telera, M. Carosi, P. Muti, S. Strano, S. Donzelli, G. Blandino
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