Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion
Articolo
Data di Pubblicazione:
2015
Citazione:
Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion / C. Pulito, F. Mori, A. Sacconi, L. Casadei, M. Ferraiuolo, M.C. Valerio, R. Santoro, F. Goeman, A. Maidecchi, L. Mattoli, C. Manetti, S. Di Agostino, P. Muti, G. Blandino, S. Strano. - In: ONCOTARGET. - ISSN 1949-2553. - 6:20(2015), pp. 18134-18150.
Abstract:
Malignant pleural mesothelioma is a poorly treated neoplasia arising from the pleural mesothelial lining. Here we document that the leaf extract of Cynara scolymus exerts broad antitumoral effects both in vitro and in vivo on mesothelioma cell lines. We found that Cynara scolymus treatment affects strongly cell growth, migration and tumor engraftment of mesothelioma cell lines. Strikingly, dietary feeding with Cynara scolymus leaf extract reduces the growth of mesothelioma xenografted tumors similarly to pemetrexed, a commonly employed drug in the treatment of mesothelioma. In aggregate our findings suggest that leaf extract of Cynara scolymus holds therapeutic potential for the treatment of mesothelioma.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Apoptosis; Invasion; Mesothelioma; Pathway; Tumorigenicity; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Female; Humans; Lung Neoplasms; Mesothelioma; Mice; Neoplasm Invasiveness; Phytotherapy; Plant Extracts; Plant Leaves; Plants, Medicinal; Pleural Neoplasms; Signal Transduction; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays; Cynara scolymus
Elenco autori:
C. Pulito, F. Mori, A. Sacconi, L. Casadei, M. Ferraiuolo, M.C. Valerio, R. Santoro, F. Goeman, A. Maidecchi, L. Mattoli, C. Manetti, S. Di Agostino, P. Muti, G. Blandino, S. Strano
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