Preventing high-order multiple pregnancies during controlled ovarian hyperstimulation and intrauterine insemination: 3 years’ experience using low-dose recombinant follicle-stimulating hormone and gonadotropin-releasing hormone antagonists.
Articolo
Data di Pubblicazione:
2006
Citazione:
Preventing high-order multiple pregnancies during
controlled ovarian hyperstimulation and intrauterine
insemination: 3 years’ experience using low-dose
recombinant follicle-stimulating hormone and
gonadotropin-releasing hormone antagonists. / G. Ragni, I. Caliari, A.E. Nicolosi, M. Arnoldi, E. Somigliana, P.G. Crosignani. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - 85:3(2006), pp. 619-624.
Abstract:
Objective: To employ protocols of mild ovarian stimulation to prevent an excessively elevated rate of high-order
multiple pregnancies.
Design: Case series.
Setting: University hospital.
Patient(s): Six hundred and twenty one consecutive patients undergoing 1,259 controlled ovarian hyperstimulation
and intrauterine insemination cycles.
Intervention(s): Patients received 50 IU per day of recombinant follicle-stimulating hormone (FSH) starting the
third day of the cycle, then a gonadotropin-releasing hormone (GnRH) antagonist on the day in which a follicle
13 mm was visualized. Cycles were canceled if three or more follicles 16 mm and/or five or more follicles
11 mm were detected.
Main Outcome Measure(s): Rate of high-order multiple pregnancies.
Result(s): The clinical pregnancy rate per initiated cycle was 9.2% (95% confidence interval, 7.5–11.1%). The
incidence of twins and high-order multiple pregnancies was 9.5% (95% CI, 5.3–16.2%) and 0 (0.0 –3.2%),
respectively.
Conclusion(s): In controlled ovarian hyperstimulation and intrauterine insemination cycles, a protocol of 50 IU
of recombinant FSH daily combined with the use of GnRH antagonists and a policy of strict cancellation based on
echographic criteria are associated with a satisfactory pregnancy rate per initiated cycle and a low risk of high-order
multiple pregnancies.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Intrauterine insemination, mild ovarian hyperstimulation, multiple pregnancy
Elenco autori:
G. Ragni, I. Caliari, A.E. Nicolosi, M. Arnoldi, E. Somigliana, P.G. Crosignani
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