Radiofrequency versus microwave ablation for treatment of the lung tumours: LUMIRA (lung microwave radiofrequency) randomized trial
Articolo
Data di Pubblicazione:
2017
Citazione:
Radiofrequency versus microwave ablation for treatment of the lung tumours: LUMIRA (lung microwave radiofrequency) randomized trial / M. Macchi, M.P. Belfiore, C. Floridi, N. Serra, G. Belfiore, L. Carmignani, R.F. Grasso, E. Mazza, C. Pusceddu, L. Brunese, G. Carrafiello. - In: MEDICAL ONCOLOGY. - ISSN 1357-0560. - 34:5(2017), pp. 96.1-96.10. [10.1007/s12032-017-0946-x]
Abstract:
The LUMIRA trial evaluated the effectiveness of radiofrequency (RFA) and microwave ablation (MWA) in lung tumours ablation and defining more precisely their fields of application. It is a controlled prospective multi-centre random trial with 1:1 randomization. Fifty-two patients in stage IV disease (15 females and 37 males, mean age 69 y.o., range 40–87) were included. We randomized the patients in two different subgroups: MWA group and RFA group. For each group, we evaluated the technical and clinical success, the overall survival and complication rate. Inter-group difference was compared using Chi-square test or Fisher’s exact test for categorical variables and one-way ANOVA test for continuous variables. For RFA group, there was a significant reduction in tumour size only between 6 and 12 months (p value = 0.0014). For MWA group, there was a significant reduction in tumour size between 6 and 12 months (p value = 0.0003) and between pre-therapy and 12 months (p value = 0.0215). There were not significant differences between the two groups in terms of survival time (p value = 0.883), while the pain level in MWA group was significantly less than in RFA group (1.79 < 3.25, p value = 0.0043). In conclusion, our trial confirms RFA and MWA are both excellent choices in terms of efficacy and safety in lung tumour treatments. However, when compared to RFA therapy, MWA produced a less intraprocedural pain and a significant reduction in tumour mass.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Ablation treatment; Lung cancer; Microwave; Radiofrequency; Adult; Aged; Aged, 80 and over; Catheter Ablation; Female; Humans; Lung Neoplasms; Male; Microwaves; Middle Aged; Neoplasm Staging; Prospective Studies
Elenco autori:
M. Macchi, M.P. Belfiore, C. Floridi, N. Serra, G. Belfiore, L. Carmignani, R.F. Grasso, E. Mazza, C. Pusceddu, L. Brunese, G. Carrafiello
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