Longitudinal investigation of the parietal lobe anatomy in bipolar disorder and its association with general functioning
Articolo
Data di Pubblicazione:
2017
Citazione:
Longitudinal investigation of the parietal lobe anatomy in bipolar disorder and its association with general functioning / A. Ferro, C. Bonivento, G. Delvecchio, M. Bellani, C. Perlini, N. Dusi, V. Marinelli, M. Ruggeri, A.C. Altamura, B. Crespo-Facorro, P. Brambilla. - In: PSYCHIATRY RESEARCH. NEUROIMAGING. - ISSN 0925-4927. - 267(2017 Sep 30), pp. 22-31. [10.1016/j.pscychresns.2017.06.010]
Abstract:
The parietal lobe (PL) supports cognitive domains, including attention and memory, which are impaired in bipolar disorder (BD). Although cross-sectional voxel-based morphometry studies found reduced PL grey matter (GM) in BD, none has longitudinally focused on PL anatomy in BD, relating it to patients' functioning. Thirty-eight right-handed BD patients and 42 matched healthy subjects (HS) underwent a Magnetic Resonance Imaging (MRI) scan at baseline. Seventeen BD patients and 16 matched HS underwent a follow-up MRI. PL white matter (WM) and GM volumes were measured. The trajectory of parietal volumes over time and the possible relation with the global functioning were investigated in both BD patients and HS. At baseline, BD patients showed significant reduced PL WM and GM and different WM laterality compared with HS. Furthermore, smaller PL WM volumes predicted lower global functioning in BD, but not in HS. At follow-up, although BD patients reported reduced PL WM compared with HS, no different pattern of volume changes over time was detected between groups. This study suggests the involvement of the PL in the pathophysiology of BD. In particular, PL WM reductions seem to predict an impairment in general functioning in BD and might represent a marker of functional outcome.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Asymmetry; Brain volumes; Grey matter; Magnetic resonance imaging; White matter; Adult; Attention; Bipolar Disorder; Case-Control Studies; Cross-Sectional Studies; Female; Functional Laterality; Gray Matter; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Memory; Middle Aged; Organ Size; Parietal Lobe; White Matter
Elenco autori:
A. Ferro, C. Bonivento, G. Delvecchio, M. Bellani, C. Perlini, N. Dusi, V. Marinelli, M. Ruggeri, A.C. Altamura, B. Crespo-Facorro, P. Brambilla
Link alla scheda completa: