Superior relative efficacy of live attenuated influenza vaccine compared with inactivated influenza vaccine in young children with recurrent respiratory tract infections.
Articolo
Data di Pubblicazione:
2006
Citazione:
Superior relative efficacy of live attenuated influenza vaccine compared with inactivated influenza vaccine in young children with recurrent respiratory tract infections / S. Ashkenazi,A. Vertruyen, J. Aristegui, S. Esposito, DD. McKeith, T. Klemola, J. Biolek, J. Kuhr, T. Bujnowski, D. Desgrandshamps, SM. Cheng, J. Skineer, WC. Gruber, BD. Forrest for the CAIV-T study group. - In: THE PEDIATRIC INFECTIOUS DISEASE JOURNAL. - ISSN 0891-3668. - 25:10(2006), pp. 870-879. [10.1097/01.inf.0000237829.66310.85]
Abstract:
BACKGROUND: Young children have a high incidence of influenza and influenza-related complications. This study compared the efficacy and safety of cold-adapted influenza vaccine, trivalent (CAIV-T) with trivalent inactivated influenza vaccine (TIV) in young children with a history of recurrent respiratory tract infections (RTIs). METHODS: Children 6 to 71 months of age were randomized to receive 2 doses of CAIV-T (n = 1101) or TIV (n = 1086), 35 ± 7 days apart before the start of the 2002-2003 influenza season and were followed up for culture-confirmed influenza, effectiveness outcomes, reactogenicity, and adverse events. RESULTS: Overall, 52.7% (95% confidence interval [CI] = 21.6%-72.2%) fewer cases of influenza caused by virus strains antigenically similar to vaccine were observed in CAIV-T than in TIV recipients. Greater relative efficacy for CAIV-T was observed for the antigenically similar A/H1N1 (100.0%; 95% CI = 42.3%-100.0%) and B (68.0%; 95% CI = 37.3%-84.8%) strains but not for the antigenically similar A/H3N2 strains (-97.1%; 95% CI = -540.2% to 31.5%). Relative to TIV, CAIV-T reduced the number of RTI-related healthcare provider visits by 8.9% (90% CI = 1.5%-15.8%) and missed days of school, kindergarten, or day care by 16.2% (90% CI = 10.4%-21.6%). Rhinitis and rhinorrhea, otitis media, and decreased appetite were the only events that were reported more frequently in CAIV-T subjects. There was no difference between groups in the incidence of wheezing after vaccination. CONCLUSIONS: CAIV-T was well tolerated in these children with RTIs and demonstrated superior relative efficacy compared with TIV in preventing influenza illness. Copyright
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
S. Ashkenazi, A. Vertruyen, J. Aristegui, S. Esposito, D.D. Mckeith, T. Klemola, J. Biolek, J. Kuhr, T. Bujnowski, D. Desgrandshamps, S.M. Cheng, J. Skineer, W.C. Gruber, B.D.F.F.T.C.T. study group
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