Data di Pubblicazione:
2004
Citazione:
Polycomb group proteins in cell cycle progression and cancer / D. Pasini, P. Bracken Adrian, K. Helin. - In: CELL CYCLE. - ISSN 1538-4101. - 3:4(2004), pp. 396-400.
Abstract:
Epigenetic deregulation of gene expression is emerging as key mechanism in tumorigenesis. Deregulated activity of the chromatin remodeling Polycomb Repressive Complex 2 (PRC2) has recently been shown to be a frequent event in human tumors. Here we discuss these findings and speculate on the role of the PRC2 complex in controlling gene expression during normal cellular proliferation and cancer development.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
polycomb group; PRC2; epigenetics; histone methyl transferase; E2F; EZH2
Elenco autori:
D. Pasini, P. Bracken Adrian, K. Helin
Link alla scheda completa: