Automated cortical thickness and skewness feature selection in bipolar disorder using a semi-supervised learning method
Articolo
Data di Pubblicazione:
2019
Citazione:
Automated cortical thickness and skewness feature selection in bipolar disorder using a semi-supervised learning method / L. Squarcina, T.M. Dagnew, M.W. Rivolta, M. Bellani, R. Sassi, P. Brambilla. - In: JOURNAL OF AFFECTIVE DISORDERS. - ISSN 0165-0327. - 256(2019), pp. 416-423. [10.1016/j.jad.2019.06.019]
Abstract:
Background
Bipolar disorder (BD) broadly affects brain structure, in particular areas involved in emotion processing and cognition. In the last years, the psychiatric field's interest in machine learning approaches has been steadily growing, thanks to the potentiality of automatically discriminating patients from healthy controls.
Methods
In this work, we employed cortical thickness of 58 regions of interest obtained from magnetic resonance imaging scans of 41 BD patients and 34 healthy controls, to automatically identify the regions which are mostly involved with the disease. We used a semi-supervised method, addressing the criticisms on supervised methods, related to the fact that the diagnosis is not unaffected by uncertainty.
Results
Our results confirm findings in previous studies, with a classification accuracy of about 75% when mean thickness and skewness of up to five regions are considered. We obtained that the parietal lobe and some areas in the temporal sulcus were the regions which were the most involved with BD.
Limitations
The major limitation of our work is the limited size or our dataset, but in line with other recent machine learning works in the field. Moreover, we considered chronic patients, whose brain characteristics may thus be affected.
Conclusions
The automatic selection of the brain regions most involved in BD may be of great importance when dealing with the pathogenesis of the disorder. Our method selected regions which are known to be involved with BD, indicating that damage to the identified areas can be considered as a marker of disease.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Bipolar disorder; Classification; MRI pattern recognition; Machine learning; Magnetic resonance imaging; Neuroimaging; Semi-supervised learning
Elenco autori:
L. Squarcina, T.M. Dagnew, M.W. Rivolta, M. Bellani, R. Sassi, P. Brambilla
Link alla scheda completa: